User:Mr. Ibrahem/Methocarbamol

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Mr. Ibrahem/Methocarbamol
Clinical data
Trade namesRobaxin, Marbaxin, others
AHFS/Drugs.comMonograph
MedlinePlusa682579
License data
Pregnancy
category
  • AU: B2
Routes of
administration		By mouth, intravenous
Drug classMuscle relaxant[1]
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver
Elimination half-life1.14–1.24 hours[3]
Identifiers
  • (RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
Chemical and physical data
FormulaC11H15NO5
Molar mass241.243 g·mol−1
3D model (JSmol)
  • O=C(OCC(O)COc1ccccc1OC)N
  • InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14) checkY
  • Key:GNXFOGHNGIVQEH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain.[1][4] It may be used together with rest, physical therapy, and pain medication.[1][8][9] It is less preferred in low back pain.[1] It has limited use for rheumatoid arthritis and cerebral palsy.[1][10] Effects generally begin within half an hour.[1] It is taken by mouth or injection into a vein.[1]

Common side effect include headaches, sleepiness, dizziness.[1][5] Serious side effects may include anaphylaxis, liver problems, confusion, and seizures.[4] Use is not recommended in pregnancy and breastfeeding.[1][4] Use by the elderly is considered high risk.[1] Methocarbamol is a centrally acting muscle relaxant.[1] How it works is unclear, but it does not appear to affect muscles directly.[1]

Methocarbamol was approved for medical use in the United States in 1957.[1] It is available as a generic medication.[1][4] It is relatively inexpensive as of 2016.[11] In 2017, it was the 178th most commonly prescribed medication in the United States, with more than three million prescriptions.[12][13]

References[edit]

  1. ^ a b c d e f g h i j k l m n o p "Methocarbamol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 4 March 2021. Retrieved 8 April 2019.
  2. ^ "Robaxin-750 - Summary of Product Characteristics (SmPC)". (emc). 8 August 2017. Archived from the original on 29 August 2021. Retrieved 19 April 2020.
  3. ^ Sica DA, Comstock TJ, Davis J, Manning L, Powell R, Melikian A, Wright G (1990). "Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals". European Journal of Clinical Pharmacology. 39 (2): 193–4. doi:10.1007/BF00280060. PMID 2253675.
  4. ^ a b c d e British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1093. ISBN 9780857113382.
  5. ^ a b "Methocarbamol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 30 January 2017. PMID 31643609. Archived from the original on 28 August 2021. Retrieved 18 April 2020.
  6. ^ "Methocarbamol Use During Pregnancy". Drugs.com. 10 April 2020. Archived from the original on 23 January 2021. Retrieved 19 April 2020.
  7. ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 21 January 2021. Retrieved 8 September 2020.
  8. ^ "Robaxin- methocarbamol tablet, film coated". DailyMed. 18 July 2019. Archived from the original on 22 October 2020. Retrieved 19 April 2020.
  9. ^ "Robaxin- methocarbamol injection". DailyMed. 10 December 2018. Archived from the original on 28 August 2021. Retrieved 19 April 2020.
  10. ^ Richards, Bethan L.; Whittle, Samuel L.; Buchbinder, Rachelle (2012-01-18). "Muscle relaxants for pain management in rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 1: CD008922. doi:10.1002/14651858.CD008922.pub2. ISSN 1469-493X. PMID 22258993.
  11. ^ Fine, Perry G. (2016). The Hospice Companion: Best Practices for Interdisciplinary Care of Advanced Illness. Oxford University Press. p. PT146. ISBN 978-0-19-045692-4.
  12. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  13. ^ "Methocarbamol - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.
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