User:Mr. Ibrahem/Mitomycin C

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Mr. Ibrahem/Mitomycin C
Skeletal formula
Ball-and-stick model of the molecular structure determined by X-ray crystallography[1]
Clinical data
Trade namesMitosol, Mutamycin, Jelmyto, others
Other namesMitomycin, UGN-101
AHFS/Drugs.comMonograph
MedlinePlusa682415
License data
Pregnancy
category
Routes of
administration		Intravenous, topical
Drug classAntineoplastic agent
Legal status
Legal status
Pharmacokinetic data
MetabolismLiver
Elimination half-life8–48 min
Identifiers
  • {11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl}methyl carbamate
Chemical and physical data
FormulaC15H18N4O5
Molar mass334.332 g·mol−1
3D model (JSmol)
Melting point360 °C (680 °F)
Solubility in water8.43 g L−1
  • CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N
  • InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1 checkY
  • Key:NWIBSHFKIJFRCO-WUDYKRTCSA-N

Mitomycin C, sold under the brand name Mutamycin among others, is a medication used to treat cancer including bladder cancer, breast cancer, pancreatic cancer, and non-small cell lung cancer (NSCLC).[3] It is given by injection into a vein.[4]

Common side effects include bone marrow suppression, cough, bleeding, tiredness, nausea, rash, and low platelets.[3] Other side effects may include hair loss, fever, hemolytic uremic syndrome, and liver problems.[3][4] Use in pregnancy may harm the baby.[3] It is in the family of mitomycins.[5]

Mitomycin C was isolated in 1958.[5] It is available as a generic medication. In the United Kingdom 40 mg costs the NHS about £76 as of 2021.[3] This amount in the United States costs about 430 USD.[6] It is made by Streptomyces caespitosus.[4]

References[edit]

  1. ^ "KUWQIF: Mitomycin C Dihydrate, also known as (6-amino-8a-methoxy-5-methyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate dihydrate". Cambridge Structural Database: Access Structures. Cambridge Crystallographic Data Centre. doi:10.5517/ccv38nv. Archived from the original on 19 November 2021. Retrieved 2021-11-03.
  2. ^ a b "Mitomycin (Mutamycin) Use During Pregnancy". Drugs.com. 19 August 2019. Archived from the original on 22 October 2020. Retrieved 15 April 2020.
  3. ^ a b c d e f g BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 964. ISBN 978-0857114105.
  4. ^ a b c "Mitomycin Monograph for Professionals". Drugs.com. Archived from the original on 6 March 2021. Retrieved 18 November 2021.
  5. ^ a b Advances in Molecular Toxicology. Elsevier. 6 December 2012. p. 244. ISBN 978-0-444-59402-0. Archived from the original on 19 November 2021. Retrieved 18 November 2021.
  6. ^ "Mitomycin Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 12 August 2020. Retrieved 18 November 2021.
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