User:Mr. Ibrahem/Mitotane

Mr. Ibrahem/Mitotane
Clinical data
Trade names	Lysodren
Other names	1,1-(Dichlorodiphenyl)-2,2-dichloroethane; o,p'-DDD
AHFS/Drugs.com	Monograph
MedlinePlus	a608050
License data	EU EMA: by INN; US FDA: MITOTANE;
Pregnancy; category	C;
Routes of; administration	By mouth
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	40%
Protein binding	6%
Elimination half-life	18–159 days
Identifiers
	IUPAC name (RS)-1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)-ethyl]-benzene;
Chemical and physical data
Formula	C14H10Cl4
Molar mass	320.03 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
Melting point	76 to 78 °C (169 to 172 °F)
	SMILES Clc1ccccc1C(c2ccc(Cl)cc2)C(Cl)Cl;
	InChI InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H ; Key:JWBOIMRXGHLCPP-UHFFFAOYSA-N ;
	(verify)

Mitotane, sold under the brand name Lysodren among others, is a medication used to treat adrenocortical carcinoma and Cushing's syndrome.^[1] It is taken by mouth.^[1] During treatment corticosteroids are often needed.^[1]

Common side effects include loss of appetite, nausea, diarrhea, sleepiness, and rash.^[1] Other complications may include bleeding from the cancers, brain damage, and adrenal insufficiency.^[1] Use during pregnancy may harm the baby.^[2] It works by blocking the adrenal cortex.^[3]

Mitotane was introduced for medical use in 1960.^[4] In the United Kingdom 100 tablets of 0.5 mg costs the NHS about £590 as of 2021.^[3] This amount in the United States is about 1,100 USD.^[5]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g "Mitotane Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2016. Retrieved 18 November 2021.
^ "Mitotane (Lysodren) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 18 November 2021.
^ ^a ^b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 979. ISBN 978-0857114105.
^ Marcello D. Bronstein (1 October 2010). Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment. Springer Science & Business Media. pp. 156–. ISBN 978-1-60327-449-4.
^ "Lysodren Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 17 January 2021. Retrieved 18 November 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g "Mitotane Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2016. Retrieved 18 November 2021.

[2] "Mitotane (Lysodren) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 18 November 2021.

[BNF81-3] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 979. ISBN 978-0857114105.

[Bro2010-4] Marcello D. Bronstein (1 October 2010). Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment. Springer Science & Business Media. pp. 156–. ISBN 978-1-60327-449-4.

[5] "Lysodren Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 17 January 2021. Retrieved 18 November 2021.

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