User:Mr. Ibrahem/Olsalazine

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Mr. Ibrahem/Olsalazine
Clinical data
Trade namesDipentum
Other namesOlsalazine sodium
AHFS/Drugs.comMonograph
MedlinePlusa601088
License data
Pregnancy
category
Routes of
administration		By mouth
Drug class5-ASA derivative[2]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Protein binding99%
Elimination half-life0.9 hours
Chemical and physical data
FormulaC14H10N2O6
Molar mass302.242 g·mol−1
3D model (JSmol)
  • O=C(O)c1cc(ccc1O)/N=N/c2cc(C(O)=O)c(O)cc2
  • InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)/b16-15+ checkY
  • Key:QQBDLJCYGRGAKP-FOCLMDBBSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Olsalazine, sold under the brand name Dipentum among others, is a medication used to treat ulcerative colitis and Crohn’s disease.[2][3] It is used in people who cannot take sulfasalazine.[2] It is taken by mouth in the form of tablet or capsule.[4] If needed, contents of the capsule can be sprinkled on food.[4]

Side effects are uncommon but include numbess and a fast heart beat.[4] Other side effects may include diarrhea, nausea, heartburn, tiredness, and headache.[2] Caution is advised in kidney problems.[4] It is broken down into mesalazine (5-ASA) in the colon by which it acts.[3] 5-ASA than inhibits cyclooxygenase and lipoxygenase thereby reducing prostoglandin and leukotriene production.[2]

Olsalazine was approved for medical use in the United States in 1990.[2] It is available as a generic medication.[4] In the United Kingdom a months supply costs the NHS around £150 as of 2021.[4] In the United States this amount costs about 1,600 USD.[5]

References[edit]

  1. ^ a b "Olsalazine (Dipentum) Use During Pregnancy". Drugs.com. 6 September 2019. Archived from the original on 18 January 2021. Retrieved 9 October 2020.
  2. ^ a b c d e f g "Olsalazine Monograph for Professionals". Drugs.com. Archived from the original on 18 January 2021. Retrieved 7 November 2021.
  3. ^ a b c "Olsalazine Sodium 250 mg Capsules - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Archived from the original on 12 January 2021. Retrieved 9 January 2021.
  4. ^ a b c d e f g h "1. Gastro-intestinal system". British National Formulary (BNF) (82 ed.). London: BMJ Group and the Pharmaceutical Press. September 2021 – March 2022. p. 47. ISBN 978-0-85711-413-6.{{cite book}}: CS1 maint: date format (link)
  5. ^ "Olsalazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 7 November 2021.
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