User:Mr. Ibrahem/Oxazepam
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Clinical data | |
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Trade names | Serax, Alepam, others |
AHFS/Drugs.com | Monograph |
Routes of administration | By mouth |
Drug class | Benzodiazepine[1] |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 92.8% |
Metabolism | Liver (glucuronidation) |
Elimination half-life | 6–9 h[2][3][4] |
Excretion | Kidney |
Identifiers | |
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Chemical and physical data | |
Formula | C15H11ClN2O2 |
Molar mass | 286.71 g·mol−1 |
3D model (JSmol) | |
Melting point | 205 to 206 °C (401 to 403 °F) |
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Oxazepam is a benzodiazepine used to treat anxiety, trouble sleeping, and alcohol withdrawal.[6][1] It is taken by mouth.[1] It has a relatively slow onset and prolonged effects.[7]
Common side effects include sleepiness, dizziness, and headache.[1] Other side effects may include abuse, agitation, memory loss, suicide, and slurred speech.[6] Use is not recommended during early pregnancy.[1] Use is not generally recommended with opioids.[1] It is believed to work via the GABA neurotransmitter.[1]
Oxazepam was patented in 1962 and approved for medical use in 1964.[8] It is available as a generic medication.[6] In the United Kingdom 28 tablets of 15 mg costs the NHS about £6 as of 2021.[6] In the United States this amount costs about 30 USD.[9]
References[edit]
- ^ a b c d e f g h i j "Oxazepam Monograph for Professionals". Drugs.com. Archived from the original on 10 February 2018. Retrieved 10 November 2021.
- ^ "Encadré 1. Anxiolytiques à demi-vie courte (< 20 heures) et sans métabolite actif par ordre alphabétique de DCI" (PDF). Archived (PDF) from the original on 2021-06-28. Retrieved 2021-09-06.
- ^ Sonne, J; Loft, S; Døssing, M; Vollmer-Larsen, A; Olesen, KL; Victor, M; Andreasen, F; Andreasen, PB (1988). "Bioavailability and pharmacokinetics of oxazepam". European Journal of Clinical Pharmacology. 35 (4): 385–9. doi:10.1007/bf00561369. PMID 3197746. S2CID 31007311.
- ^ Sonne, J; Boesgaard, S; Poulsen, H E; Loft, S; Hansen, J M; Døssing, M; Andreasen, F (November 1990). "Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism". British Journal of Clinical Pharmacology. 30 (5): 737–742. doi:10.1111/j.1365-2125.1990.tb03844.x. PMC 1368175. PMID 2271373.
- ^ CID 4616 from PubChem
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. X. ISBN 978-0857114105.
- ^ Fitzgerald, Margaret A. (14 March 2017). Nurse Practitioner Certification Examination and Practice Preparation. F.A. Davis. p. 346. ISBN 978-0-8036-6917-8. Archived from the original on 10 November 2021. Retrieved 10 November 2021.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 536. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-09-06.
- ^ "Oxazepam Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 23 April 2021. Retrieved 10 November 2021.