User:Mr. Ibrahem/Phentolamine
Clinical data | |
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Trade names | Regitine, Oraverse |
AHFS/Drugs.com | Monograph |
Routes of administration | intravenous (IV) or intramuscular (IM) |
Drug class | Alpha blocker[1] |
Legal status | |
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Pharmacokinetic data | |
Metabolism | Liver |
Onset of action | IV < 2min; IM < 20 min[1] |
Elimination half-life | 19 minutes |
Duration of action | IV up to 30 min; IM up to 4 hrs[1] |
Identifiers | |
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Chemical and physical data | |
Formula | C17H19N3O |
Molar mass | 281.359 g·mol−1 |
3D model (JSmol) | |
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Phentolamine, sold under the brand name Regitine among others, is a medication used to treat high blood pressure in pheochromocytoma, following norepinephrine entry into soft tissues, and hypertensive emergencies.[1][2] It is given by injection.[1] When injected into a vein effects occur within 2 minutes and last up to 30 minutes.[1]
Common side effects include abdominal pain, nausea, diarrhea, flushing, stuffy nose, and low blood pressure with standing.[1] Other side effects may include myocardial infarction and priapism.[1] Safety in pregnancy is unclear.[3] It is a alpha blocker.[1]
Phentolamine was approved for medical use in the United States in 1952.[1] In the United States it costs about 460 USD per dose as of 2021.[4] In the United Kingdom it is available together with aviptadil for the treatment of erectile dysfunction.[5]
References[edit]
- ^ a b c d e f g h i j k l m "Phentolamine Monograph for Professionals". Drugs.com. Archived from the original on 21 January 2021. Retrieved 28 October 2021.
- ^ a b "DailyMed - PHENTOLAMINE MESYLATE injection". dailymed.nlm.nih.gov. Archived from the original on 28 October 2021. Retrieved 28 October 2021.
- ^ "Phentolamine Use During Pregnancy". Drugs.com. Archived from the original on 27 October 2020. Retrieved 28 October 2021.
- ^ "Phentolamine Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 28 October 2021.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 866. ISBN 978-0857114105.