User:Mr. Ibrahem/Ramelteon

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Mr. Ibrahem/Ramelteon
Clinical data
Trade namesRozerem, others
AHFS/Drugs.comMonograph
MedlinePlusa605038
License data
Addiction
liability		None[1]
Routes of
administration		By mouth
Drug classMelatonin receptor agonist[2]
Legal status
Legal status
Pharmacokinetic data
Bioavailability1.8%
Protein binding~82%
MetabolismLiver (CYP1A2-mediated)
Elimination half-life1–2.6 hours
ExcretionKidney (84%) and fecal (4%)
Identifiers
  • (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]
    furan-8-yl)ethyl]propionamide
Chemical and physical data
FormulaC16H21NO2
Molar mass259.349 g·mol−1
3D model (JSmol)
  • CCC(NCC[C@@H]1CCC2=CC=C3OCCC3=C12)=O
  • InChI=1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m1/s1 checkY
  • Key:YLXDSYKOBKBWJQ-GFCCVEGCSA-N checkY
  (verify)

Ramelteon, sold under the brand name Rozerem among others, is a medication used for trouble falling asleep.[3] It is taken by mouth, half an hour before bed.[3] There is no limitation on duration of use; though long term effectiveness is unclear.[4][2]

Common side effects include sleepiness, dizziness, nausea, and worsened trouble sleeping.[3] Other side effects may include anaphylaxis, abnormal thinking, and depression.[3] Effects on pregnancy and breastfeeding are unclear.[5] It is a melatonin receptor agonist and is expected to work similar to melatonin.[2]

Ramelteon was discovered in 1996 and approved for medical use in the United States in 2005.[4][1] It was declined approval in Europe in 2008 due to unclear effectiveness.[2] In the United States it is available as a generic medication and costs about 60 USD per month as of 2021.[6] It is not a controlled substance.[1]

References[edit]

  1. ^ a b c d "Ramelteon Monograph for Professionals". Drugs.com. Archived from the original on 25 August 2019. Retrieved 15 October 2021.
  2. ^ a b c d "Ramelteon: Withdrawal of the marketing authorisation application". Archived from the original on 16 October 2021. Retrieved 15 October 2021.
  3. ^ a b c d e f "Rozerem- ramelteon tablet, film coated". DailyMed. 28 December 2018. Archived from the original on 26 March 2021. Retrieved 13 April 2020.
  4. ^ a b Neubauer DN (February 2008). "A review of ramelteon in the treatment of sleep disorders". Neuropsychiatric Disease and Treatment. 4 (1): 69–79. doi:10.2147/ndt.s483. PMC 2515902. PMID 18728808.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  5. ^ "Ramelteon (Rozerem) Use During Pregnancy". Drugs.com. Archived from the original on 24 January 2021. Retrieved 15 October 2021.
  6. ^ "Ramelteon Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 31 October 2016. Retrieved 15 October 2021.
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