User:Mr. Ibrahem/Romiplostim

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Mr. Ibrahem/Romiplostim
Clinical data
Trade namesNplate, Romiplate
Other namesAMG531
AHFS/Drugs.comMonograph
MedlinePlusa609008
License data
Pregnancy
category
  • AU: B3
Routes of
administration		Subcutaneous
Drug classColony-stimulating factor[1]
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only
  • EU: Rx-only
Pharmacokinetic data
Elimination half-life1 to 34 days
Identifiers
  • L-methionyl[human immunogloblin heavy constant gamma 1-(227 C-terminal residues)-peptide (Fc fragment)] fusion protein with 41 amino acids peptide, (7-7′:10,10′)-bisdisulfide dimer
Chemical and physical data
FormulaC2634H4086N722O790S18
Molar mass59085.01 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Romiplostim, sold under the brand name Nplate among others, is a medication used to treat immune thrombocytopenic purpura (ITP) and acute radiation syndrome.[1][2] In ITP it may be used when corticosteroids, immunoglobulins, or splenectomy are not effective.[2] It is given by injection under the skin.[2]

Common side effects include joint pain, trouble sleeping, abdominal pain, headache, and tiredness.[1] Other side effects include blood cancer, blood clots, and bone marrow fibrosis.[1] Safety in pregnancy is unclear.[3] It works to stimulate platelet production by activating the thrombopoietin receptor.[4]

Romiplostim was approved for medical use in the United States in 2008 and Europe in 2009.[4][1] In the United Kingdom a 125 mcg vial costs the NHS about £240 as of 2021.[5] This amount in the United States costs about 1,100 USD.[6]

References[edit]

  1. ^ a b c d e f g "Romiplostim Monograph for Professionals". Drugs.com. Archived from the original on 16 September 2021. Retrieved 18 October 2021.
  2. ^ a b c d "DailyMed - NPLATE- romiplostim injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 16 September 2021. Retrieved 18 October 2021.
  3. ^ "Romiplostim (Nplate) Use During Pregnancy". Drugs.com. Archived from the original on 4 December 2020. Retrieved 18 October 2021.
  4. ^ a b "Nplate". Archived from the original on 3 March 2021. Retrieved 18 October 2021.
  5. ^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1096. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
  6. ^ "Nplate Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 18 October 2021.
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