User:Mr. Ibrahem/Ticagrelor

Mr. Ibrahem/Ticagrelor
Clinical data
Trade names	Brilinta, Brilique, others
Other names	AZD-6140
AHFS/Drugs.com	Monograph
MedlinePlus	a611050
License data	EU EMA: by INN; US DailyMed: Ticagrelor; US FDA: Ticagrelor;
Pregnancy; category	AU: B1; ;
Routes of; administration	By mouth
Drug class	Adenosine diphosphate receptor inhibitor
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Bioavailability	36%
Protein binding	>99.7%
Metabolism	Liver (CYP3A4)
Elimination half-life	7 hrs (ticagrelor), 8.5 hrs (active metabolite AR-C124910XX)
Excretion	Bile duct
Identifiers
	IUPAC name (1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino]-5-(propylthio)- 3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol;
Chemical and physical data
Formula	C23H28F2N6O4S
Molar mass	522.57 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F;
	InChI InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1 ; Key:OEKWJQXRCDYSHL-FNOIDJSQSA-N ;
	(what is this?) (verify)

Ticagrelor, sold under the brand name Brilinta among others, is a medication used in acute coronary syndrome to prevent stroke and heart attacks.^[2]^[3] It is generally used with aspirin.^[2] It is taken by mouth.^[2]

Common side effects include bleeding and shortness of breath.^[2] Other side effects may include cough, diarrhea, and low blood pressure.^[3] It is a platelet aggregation inhibitor, specifically a adenosine diphosphate receptor inhibitor, which works by blocking ADP from attaching to platelets.^[2]^[1]

Ticagrelor was approved for medical use in Europe 2010,^[2] and in the United States in 2011.^[3] In the United Kingdom 4 weeks of medication costs the NHS about £55 as of 2021.^[1] In the United States this amount costs about 380 USD as of 2021.^[4]

References[edit]

^ ^a ^b ^c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 229. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ ^a ^b ^c ^d ^e ^f ^g ^h "Brilique". Archived from the original on 2 May 2021. Retrieved 3 October 2021.
^ ^a ^b ^c ^d "Ticagrelor Monograph for Professionals". Drugs.com. Archived from the original on 17 September 2020. Retrieved 3 October 2021.
^ "Brilinta Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 November 2016. Retrieved 3 October 2021.

[BNF80-1] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 229. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[EPAR2021-2] ^ ^a ^b ^c ^d ^e ^f ^g ^h "Brilique". Archived from the original on 2 May 2021. Retrieved 3 October 2021.

[AHFS2021-3] "Ticagrelor Monograph for Professionals". Drugs.com. Archived from the original on 17 September 2020. Retrieved 3 October 2021.

[4] "Brilinta Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 November 2016. Retrieved 3 October 2021.

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