User:Mr. Ibrahem/Trifluoperazine

Mr. Ibrahem/Trifluoperazine
Clinical data
Trade names	Stelazine, Eskazinyl, Eskazine, Jatroneural, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682121
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth, IM
Drug class	Typical antipsychotic
Legal status
Legal status	UK: POM (Prescription only); US: ℞-only;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	10–20 hours
Identifiers
	IUPAC name 10-[3-(4-methylpiperazin-1-yl)propyl]-; 2-(trifluoromethyl)-10H-phenothiazine;
Chemical and physical data
Formula	C21H24F3N3S
Molar mass	407.50 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4;
	InChI InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3 ; Key:ZEWQUBUPAILYHI-UHFFFAOYSA-N ;
	(verify)

Trifluoperazine, sold under the brand name Stelazine among others, is a typical antipsychotic primarily used to treat schizophrenia.^[1] It is also used, short term, for generalized anxiety disorder but is less preferred to benzodiazepines and use for nausea.^[1]^[2] It is taken by mouth.^[1]

Common side effects include movement disorders including tardive dyskinesia, sleepiness, blurry vision, dry mouth, and low blood pressure.^[1]^[3] Other severe side effects may include neuroleptic malignant syndrome, pancytopenia, and liver problems.^[1] It increases the risk of death in those with dementia.^[1] It is in the phenothiazine chemical class.^[3] It is believed to work by blocking the effects of dopamine.^[1]

Trifluoperazine was patented in 1955 and came into medical use in 1959.^[3] It is available as a generic medication.^[2] In the United States a month of medication at 5 mg twice per day costs about 27 USD as of 2021.^[4] This amount in the United Kingdom costs the NHS about £83.^[2]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Trifluoperazine Monograph for Professionals". Drugs.com. Archived from the original on 7 August 2017. Retrieved 19 September 2021.
^ ^a ^b ^c ^d BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 408. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ ^a ^b ^c ^d Buschmann, Helmut; Holenz, Jörg; Párraga, Antonio; Torrens, Antoni; Vela, José Miguel; Díaz, José Luis (16 April 2007). Antidepressants, Antipsychotics, Anxiolytics, 2 Volume Set: From Chemistry and Pharmacology to Clinical Application. John Wiley & Sons. p. 508. ISBN 978-3-527-31058-6. Archived from the original on 22 September 2021. Retrieved 19 September 2021.
^ "Trifluoperazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 September 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Trifluoperazine Monograph for Professionals". Drugs.com. Archived from the original on 7 August 2017. Retrieved 19 September 2021.

[BNF80-2] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 408. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[Bus2007-3] Buschmann, Helmut; Holenz, Jörg; Párraga, Antonio; Torrens, Antoni; Vela, José Miguel; Díaz, José Luis (16 April 2007). Antidepressants, Antipsychotics, Anxiolytics, 2 Volume Set: From Chemistry and Pharmacology to Clinical Application. John Wiley & Sons. p. 508. ISBN 978-3-527-31058-6. Archived from the original on 22 September 2021. Retrieved 19 September 2021.

[4] "Trifluoperazine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 September 2021.

[1]

[2]

[3]

[4]