User:Mr. Ibrahem/Trihexyphenidyl
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| Clinical data | |
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| Trade names | Artane, Parkin, Pacitane, Hexymer, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a682160 |
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| Routes of administration | Oral, as tablet or elixir |
| Drug class | Antimuscarinic[1] |
| Legal status | |
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| Pharmacokinetic data | |
| Onset of action | Within an hour[1] |
| Elimination half-life | 3.3-4.1 hours |
| Duration of action | Up to 12 hrs[1] |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C20H31NO |
| Molar mass | 301.474 g·mol−1 |
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Trihexyphenidyl (THP), also known as benzhexol, is a medication used to treat Parkinsonism and certain extrapyramidal symptoms that occur as a result of antipsychotic medication.[2][1] Use is not recommended in Parkinson’s disease due to side effects.[3] It is taken by mouth.[1] Onset of effects are within an hour and can last up to 12 hours.[1]
Common side effects include dry mouth, blurry vision, nausea, and dizziness.[1] Other side effects may include misuse, anxiety, trouble sleeping, and hallucinations.[3] It is in the antimuscarinic class and works by reducing cholinergic activity in the brain.[1][3]
Trihexyphenidyl was patented in 1948 and came into medical use in 1949.[4][1] It is available as a generic medication.[3] In the United Kingdom 84 tablets of 2 mg cost the NHS less than 5 pounds as of 2021.[3] In the United States it is similarly inexpensive.[5]
References[edit]
- ^ a b c d e f g h i j k "Trihexyphenidyl Monograph for Professionals". Drugs.com. Archived from the original on 3 June 2021. Retrieved 19 September 2021.
- ^ a b "TGA eBS - Product and Consumer Medicine Information Licence". www.ebs.tga.gov.au. Archived from the original on 2021-06-02. Retrieved 2020-08-20.
- ^ a b c d e BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 431. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ Association, Pharmaceutical Manufacturers (1962). Review of Drugs, 1941-1961: Single Chemical Entities Introduced in the United States and Patent Status. p. 42. Archived from the original on 2021-09-22. Retrieved 2021-09-19.
- ^ "Trihexyphenidyl Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 22 January 2021. Retrieved 19 September 2021.