User:Mr. Ibrahem/Zileuton

Mr. Ibrahem/Zileuton
Clinical data
Trade names	Zyflo, other
AHFS/Drugs.com	Monograph
MedlinePlus	a697013
License data	US FDA: Zileuton;
Routes of; administration	By mouth
Drug class	Leukotriene modifier
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	Not yet established
Protein binding	93%
Metabolism	Liver (CYP1A2, CYP2C9 and CYP3A4-mediated)
Elimination half-life	2.5 hours
Excretion	Kidney
Identifiers
	IUPAC name N-[1-(1-benzothien-2-yl)ethyl]-N-hydroxyurea;
Chemical and physical data
Formula	C11H12N2O2S
Molar mass	236.29 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C(N)N(O)C(c2sc1ccccc1c2)C;
	InChI InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) ; Key:MWLSOWXNZPKENC-UHFFFAOYSA-N ;
	(verify)

Zileuton, sold under the trade name Zyflo among others, is a medication used for the maintenance treatment of asthma.^[1] It may be used as an add on therapy when inhaled steroids are insufficient.^[1] It is taken by mouth two to four times per day.^[1]

Common side effects include nausea and a sore throat.^[1] Other side effects may include liver problems.^[1] It is unclear if use during pregnancy is safe, with some animal studies finding harm.^[2] It is a leukotriene modifier that blocks the production of leukotrienes.^[1]

Zileuton was approved for medical use in the United States in 1996.^[1] It is not approved in Europe.^[3] It is available as a generic medication.^[4] A month of medication in the United States costs about 900 USD as of 2021.^[4] It is available in an immediate and extended release formulation.^[1]

References[edit]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Zileuton Monograph for Professionals". Drugs.com. Archived from the original on 27 August 2019. Retrieved 4 August 2021.
^ ^a ^b "Zileuton Use During Pregnancy". Drugs.com. Archived from the original on 18 January 2021. Retrieved 4 August 2021.
^ Talbot, John; Waller, Patrick (19 November 2004). Stephens' Detection of New Adverse Drug Reactions. John Wiley & Sons. p. 151. ISBN 978-0-470-09265-1. Archived from the original on 27 August 2021. Retrieved 4 August 2021.
^ ^a ^b "Zileuton ER Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 13 June 2018. Retrieved 4 August 2021.

[AHFS2021-1] ^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ ^j ^k "Zileuton Monograph for Professionals". Drugs.com. Archived from the original on 27 August 2019. Retrieved 4 August 2021.

[Preg2021-2] "Zileuton Use During Pregnancy". Drugs.com. Archived from the original on 18 January 2021. Retrieved 4 August 2021.

[3] Talbot, John; Waller, Patrick (19 November 2004). Stephens' Detection of New Adverse Drug Reactions. John Wiley & Sons. p. 151. ISBN 978-0-470-09265-1. Archived from the original on 27 August 2021. Retrieved 4 August 2021.

[GX2021-4] "Zileuton ER Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 13 June 2018. Retrieved 4 August 2021.

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