User:Mr. Ibrahem/Zolmitriptan

Mr. Ibrahem/Zolmitriptan
Clinical data
Trade names	Zomig, others
AHFS/Drugs.com	Monograph
MedlinePlus	a601129
License data	US DailyMed: Zolmitriptan;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth, nasal spray
Drug class	Triptan
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	40% (by mouth)
Protein binding	25%
Metabolism	Liver (CYP1A2-mediated, to active metabolite)
Elimination half-life	3 hours
Excretion	Kidney (65%) and fecal (35%)
Identifiers
	IUPAC name (S)-4-({3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl}methyl)-1,3-oxazolidin-2-one;
Chemical and physical data
Formula	C16H21N3O2
Molar mass	287.363 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1OC[C@@H](N1)Cc2ccc3c(c2)c(c[nH]3)CCN(C)C;
	InChI InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1 ; Key:ULSDMUVEXKOYBU-ZDUSSCGKSA-N ;
	(verify)

Zolmitriptan, sold under the brand name Zomig among others, is a medication used to treat migraine attacks and cluster headaches.^[3] It may also be used to prevent menstrual migraines.^[3] It is used as a tablet by mouth or as a nose spray.^[3]

Common side effects include tingling, nausea, dry mouth, and dizziness.^[2] Other side effects may include medication overuse headaches.^[2] Serious side effects may include coronary vasospasm, stroke, high blood pressure, anaphylaxis, and serotonin syndrome.^[2] It is unclear if use during pregnancy or breastfeeding is safe.^[1]^[3] It is a triptan that works as a selective serotonin receptor agonist of the 1B and 1D subtypes.^[2]

Zolmitriptan was patented in 1990 and approved for medical use in 1997.^[4] It is avaliable as a generic medication.^[3] In the United Kingdom 6 doses costs the NHS about £12 as of 2020.^[3] This amount in the United States costs about 30 USD as of 2021.^[5]

References[edit]

^ ^a ^b ^c "Zolmitriptan Use During Pregnancy". Drugs.com. Archived from the original on 26 November 2020. Retrieved 4 August 2021.
^ ^a ^b ^c ^d ^e ^f ^g "Zolmitriptan Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 3 August 2021.
^ ^a ^b ^c ^d ^e ^f ^g ^h BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 504. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 531. ISBN 9783527607495. Archived from the original on 2020-10-23. Retrieved 2021-01-20.
^ "Zolmitriptan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 3 August 2021.

[Preg2021-1] "Zolmitriptan Use During Pregnancy". Drugs.com. Archived from the original on 26 November 2020. Retrieved 4 August 2021.

[AHFS2021-2] ^ ^a ^b ^c ^d ^e ^f ^g "Zolmitriptan Monograph for Professionals". Drugs.com. Archived from the original on 12 August 2020. Retrieved 3 August 2021.

[BNF80-3] ^ ^a ^b ^c ^d ^e ^f ^g ^h BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 504. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 531. ISBN 9783527607495. Archived from the original on 2020-10-23. Retrieved 2021-01-20.

[GX2021-5] "Zolmitriptan Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 3 August 2021.

[1]

[2]

[3]

[4]

[5]