Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 01:02, 10 November 2007 (UTC)[edit]
Proteins without matches (19)[edit]
Proteins with a High Potential Match (6)[edit]
Created (7)[edit]
Manual Inspection (Page not found) (18)[edit]
Protein Status Grid - Date: 01:02, 10 November 2007 (UTC)[edit]
Vebose Log - Date: 01:02, 10 November 2007 (UTC)[edit]
- INFO: Beginning work on ALAD... {November 9, 2007 4:24:49 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ALAD image.jpg {November 9, 2007 4:25:51 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 4:26:05 PM PST}
- CREATED: Created new protein page: ALAD {November 9, 2007 4:26:12 PM PST}
- INFO: Beginning work on APRT... {November 9, 2007 4:26:12 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein APRT image.jpg {November 9, 2007 4:27:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:27:28 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_APRT_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ore.
| PDB = {{PDB2|1ore}}, {{PDB2|1zn7}}, {{PDB2|1zn8}}, {{PDB2|1zn9}}
| Name = Adenine phosphoribosyltransferase
| HGNCid = 626
| Symbol = APRT
| AltSymbols =; AMP; DKFZp686D13177; MGC125856; MGC125857; MGC129961
| OMIM = 102600
| ECnumber =
| Homologene = 413
| MGIid = 88061
| GeneAtlas_image1 = PBB_GE_APRT_213892_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_APRT_203219_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003999 |text = adenine phosphoribosyltransferase activity}} {{GNF_GO|id=GO:0016208 |text = AMP binding}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006166 |text = purine ribonucleoside salvage}} {{GNF_GO|id=GO:0006168 |text = adenine salvage}} {{GNF_GO|id=GO:0009116 |text = nucleoside metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 353
| Hs_Ensembl = ENSG00000198931
| Hs_RefseqProtein = NP_000476
| Hs_RefseqmRNA = NM_000485
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 87403378
| Hs_GenLoc_end = 87405843
| Hs_Uniprot = P07741
| Mm_EntrezGene = 11821
| Mm_Ensembl = ENSMUSG00000006589
| Mm_RefseqmRNA = NM_009698
| Mm_RefseqProtein = NP_033828
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 125460727
| Mm_GenLoc_end = 125462950
| Mm_Uniprot = Q564P4
}}
}}
'''Adenine phosphoribosyltransferase''', also known as '''APRT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: APRT adenine phosphoribosyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=353| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Tischfield JA, Engle SJ, Gupta PK, ''et al.'' |title=Germline and somatic mutation at the APRT locus of mice and man. |journal=Adv. Exp. Med. Biol. |volume=370 |issue= |pages= 661-4 |year= 1995 |pmid= 7660991 |doi= }}
*{{cite journal | author=Takeuchi H, Kaneko Y, Fujita J, Yoshida O |title=A case of a compound heterozygote for adenine phosphoribosyltransferase deficiency (APRT*J/APRT*Q0) leading to 2,8-dihydroxyadenine urolithiasis: review of the reported cases with 2,8-dihydroxyadenine stones in Japan. |journal=J. Urol. |volume=149 |issue= 4 |pages= 824-6 |year= 1993 |pmid= 8455250 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCR6... {November 9, 2007 4:27:28 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 4:28:15 PM PST}
- CREATED: Created new protein page: CCR6 {November 9, 2007 4:28:22 PM PST}
- INFO: Beginning work on COL10A1... {November 9, 2007 4:28:22 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein COL10A1 image.jpg {November 9, 2007 4:29:17 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:29:25 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_COL10A1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gr3.
| PDB = {{PDB2|1gr3}}
| Name = Collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)
| HGNCid = 2185
| Symbol = COL10A1
| AltSymbols =;
| OMIM = 120110
| ECnumber =
| Homologene = 55466
| MGIid = 88445
| GeneAtlas_image1 = PBB_GE_COL10A1_217428_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_COL10A1_205941_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005581 |text = collagen}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1300
| Hs_Ensembl = ENSG00000123500
| Hs_RefseqProtein = NP_000484
| Hs_RefseqmRNA = NM_000493
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 116546791
| Hs_GenLoc_end = 116553989
| Hs_Uniprot = Q03692
| Mm_EntrezGene = 12813
| Mm_Ensembl = ENSMUSG00000039462
| Mm_RefseqmRNA = NM_009925
| Mm_RefseqProtein = NP_034055
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 34079251
| Mm_GenLoc_end = 34087720
| Mm_Uniprot = Q05306
}}
}}
'''Collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)''', also known as '''COL10A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).<ref>{{cite web | title = Entrez Gene: COL10A1 collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1300| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Kuivaniemi H, Tromp G, Prockop DJ |title=Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels. |journal=Hum. Mutat. |volume=9 |issue= 4 |pages= 300-15 |year= 1997 |pmid= 9101290 |doi= 10.1002/(SICI)1098-1004(1997)9:4<300::AID-HUMU2>3.0.CO;2-9 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CRYGD... {November 9, 2007 4:29:25 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CRYGD image.jpg {November 9, 2007 4:29:59 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:30:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CRYGD_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1h4a.
| PDB = {{PDB2|1h4a}}, {{PDB2|1hk0}}, {{PDB2|2g98}}
| Name = Crystallin, gamma D
| HGNCid = 2411
| Symbol = CRYGD
| AltSymbols =; CACA; CCA3; CRYG4; cry-g-D
| OMIM = 123690
| ECnumber =
| Homologene = 36213
| MGIid = 88524
| GeneAtlas_image1 = PBB_GE_CRYGD_207532_at_tn.png
| Function = {{GNF_GO|id=GO:0005212 |text = structural constituent of eye lens}}
| Component =
| Process = {{GNF_GO|id=GO:0001654 |text = eye development}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1421
| Hs_Ensembl = ENSG00000118231
| Hs_RefseqProtein = NP_008822
| Hs_RefseqmRNA = NM_006891
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 208694577
| Hs_GenLoc_end = 208697458
| Hs_Uniprot = P07320
| Mm_EntrezGene = 12967
| Mm_Ensembl = ENSMUSG00000067299
| Mm_RefseqmRNA = NM_007776
| Mm_RefseqProtein = NP_031802
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 64996115
| Mm_GenLoc_end = 64997697
| Mm_Uniprot = Q6PGI0
}}
}}
'''Crystallin, gamma D''', also known as '''CRYGD''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.<ref>{{cite web | title = Entrez Gene: CRYGD crystallin, gamma D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1421| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Graw J |title=The crystallins: genes, proteins and diseases. |journal=Biol. Chem. |volume=378 |issue= 11 |pages= 1331-48 |year= 1998 |pmid= 9426193 |doi= }}
*{{cite journal | author=Slingsby C, Clout NJ |title=Structure of the crystallins. |journal=Eye (London, England) |volume=13 ( Pt 3b) |issue= |pages= 395-402 |year= 2000 |pmid= 10627816 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CYP7A1... {November 9, 2007 4:30:16 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:31:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cytochrome P450, family 7, subfamily A, polypeptide 1
| HGNCid = 2651
| Symbol = CYP7A1
| AltSymbols =; CP7A; CYP7; MGC126826; MGC138389
| OMIM = 118455
| ECnumber =
| Homologene = 30987
| MGIid = 106091
| GeneAtlas_image1 = PBB_GE_CYP7A1_207406_at_tn.png
| Function = {{GNF_GO|id=GO:0004497 |text = monooxygenase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0008123 |text = cholesterol 7-alpha-monooxygenase activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006699 |text = bile acid biosynthetic process}} {{GNF_GO|id=GO:0006707 |text = cholesterol catabolic process}} {{GNF_GO|id=GO:0008202 |text = steroid metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1581
| Hs_Ensembl = ENSG00000167910
| Hs_RefseqProtein = NP_000771
| Hs_RefseqmRNA = NM_000780
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 8
| Hs_GenLoc_start = 59565292
| Hs_GenLoc_end = 59575275
| Hs_Uniprot = P22680
| Mm_EntrezGene = 13122
| Mm_Ensembl = ENSMUSG00000028240
| Mm_RefseqmRNA = NM_007824
| Mm_RefseqProtein = NP_031850
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 6192759
| Mm_GenLoc_end = 6202778
| Mm_Uniprot = Q8BFR7
}}
}}
'''Cytochrome P450, family 7, subfamily A, polypeptide 1''', also known as '''CYP7A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body.<ref>{{cite web | title = Entrez Gene: CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1581| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schwarz M, Lund EG, Russell DW |title=Two 7 alpha-hydroxylase enzymes in bile acid biosynthesis. |journal=Curr. Opin. Lipidol. |volume=9 |issue= 2 |pages= 113-8 |year= 1998 |pmid= 9559267 |doi= }}
*{{cite journal | author=Davis RA, Miyake JH, Hui TY, Spann NJ |title=Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP. |journal=J. Lipid Res. |volume=43 |issue= 4 |pages= 533-43 |year= 2002 |pmid= 11907135 |doi= }}
*{{cite journal | author=Beigneux A, Hofmann AF, Young SG |title=Human CYP7A1 deficiency: progress and enigmas. |journal=J. Clin. Invest. |volume=110 |issue= 1 |pages= 29-31 |year= 2002 |pmid= 12093884 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DAZ1... {November 9, 2007 4:31:06 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:33:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Deleted in azoospermia 1
| HGNCid = 2682
| Symbol = DAZ1
| AltSymbols =; DAZ; SPGY; DAZ1; pDP1680; pDP1681
| OMIM = 400003
| ECnumber =
| Homologene = 88435
| MGIid =
| GeneAtlas_image1 = PBB_GE_DAZ1_207912_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DAZ1_208281_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_DAZ1_208282_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008494 |text = translation activator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0045948 |text = positive regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1617
| Hs_Ensembl = ENSG00000205916
| Hs_RefseqProtein = NP_004072
| Hs_RefseqmRNA = NM_004081
| Hs_GenLoc_db =
| Hs_GenLoc_chr = Y
| Hs_GenLoc_start = 25389368
| Hs_GenLoc_end = 25462575
| Hs_Uniprot =
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Deleted in azoospermia 1''', also known as '''DAZ1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains.<ref>{{cite web | title = Entrez Gene: DAZ1 deleted in azoospermia 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1617| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Foresta C, Ferlin A, Moro E, ''et al.'' |title=[Microdeletion of chromosome Y in male infertility: role of the DAZ gene] |journal=Ann. Ital. Med. Int. |volume=16 |issue= 2 |pages= 82-92 |year= 2002 |pmid= 11688365 |doi= }}
*{{cite journal | author=Fox MS, Reijo Pera RA |title=Male infertility, genetic analysis of the DAZ genes on the human Y chromosome and genetic analysis of DNA repair. |journal=Mol. Cell. Endocrinol. |volume=184 |issue= 1-2 |pages= 41-9 |year= 2002 |pmid= 11694340 |doi= }}
*{{cite journal | author=Vogt PH, Fernandes S |title=Polymorphic DAZ gene family in polymorphic structure of AZFc locus: Artwork or functional for human spermatogenesis? |journal=APMIS |volume=111 |issue= 1 |pages= 115-26; discussion 126-7 |year= 2003 |pmid= 12752250 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DCT... {November 9, 2007 4:33:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:35:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
| HGNCid = 2709
| Symbol = DCT
| AltSymbols =; TYRP2
| OMIM = 191275
| ECnumber =
| Homologene = 1447
| MGIid = 102563
| GeneAtlas_image1 = PBB_GE_DCT_205338_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DCT_205337_at_tn.png
| GeneAtlas_image3 = PBB_GE_DCT_216512_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004167 |text = dopachrome isomerase activity}} {{GNF_GO|id=GO:0005507 |text = copper ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042470 |text = melanosome}}
| Process = {{GNF_GO|id=GO:0006583 |text = melanin biosynthetic process from tyrosine}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}} {{GNF_GO|id=GO:0048468 |text = cell development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1638
| Hs_Ensembl = ENSG00000080166
| Hs_RefseqProtein = NP_001913
| Hs_RefseqmRNA = NM_001922
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 13
| Hs_GenLoc_start = 93887559
| Hs_GenLoc_end = 93929924
| Hs_Uniprot = P40126
| Mm_EntrezGene = 13190
| Mm_Ensembl = ENSMUSG00000022129
| Mm_RefseqmRNA = XM_979031
| Mm_RefseqProtein = XP_984125
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 116895153
| Mm_GenLoc_end = 116934531
| Mm_Uniprot = Q6NXI2
}}
}}
'''Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)''', also known as '''DCT''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DDX5... {November 9, 2007 4:35:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:36:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
| HGNCid = 2746
| Symbol = DDX5
| AltSymbols =; DKFZp686J01190; G17P1; HLR1; HUMP68; p68
| OMIM = 180630
| ECnumber =
| Homologene = 74312
| MGIid = 105037
| GeneAtlas_image1 = PBB_GE_DDX5_200033_at_tn.png
| GeneAtlas_image2 = PBB_GE_DDX5_200034_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003724 |text = RNA helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0016049 |text = cell growth}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1655
| Hs_Ensembl = ENSG00000108654
| Hs_RefseqProtein = NP_004387
| Hs_RefseqmRNA = NM_004396
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 59926202
| Hs_GenLoc_end = 59932872
| Hs_Uniprot = P17844
| Mm_EntrezGene = 13207
| Mm_Ensembl = ENSMUSG00000020719
| Mm_RefseqmRNA = NM_007840
| Mm_RefseqProtein = NP_031866
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 106596446
| Mm_GenLoc_end = 106604584
| Mm_Uniprot = O35662
}}
}}
'''DEAD (Asp-Glu-Ala-Asp) box polypeptide 5''', also known as '''DDX5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.<ref>{{cite web | title = Entrez Gene: DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1655| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DSG1... {November 9, 2007 4:36:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:36:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Desmoglein 1
| HGNCid = 3048
| Symbol = DSG1
| AltSymbols =; CDHF4; DG1; DSG
| OMIM = 125670
| ECnumber =
| Homologene = 1463
| MGIid = 94930
| GeneAtlas_image1 = PBB_GE_DSG1_206642_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015643 |text = toxin binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030057 |text = desmosome}}
| Process = {{GNF_GO|id=GO:0007043 |text = intercellular junction assembly}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}} {{GNF_GO|id=GO:0016339 |text = calcium-dependent cell-cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1828
| Hs_Ensembl = ENSG00000134760
| Hs_RefseqProtein = NP_001933
| Hs_RefseqmRNA = NM_001942
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 27152050
| Hs_GenLoc_end = 27190457
| Hs_Uniprot = Q02413
| Mm_EntrezGene = 13510
| Mm_Ensembl = ENSMUSG00000069441
| Mm_RefseqmRNA = XM_484705
| Mm_RefseqProtein = XP_484705
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 20454028
| Mm_GenLoc_end = 20484290
| Mm_Uniprot = Q61495
}}
}}
'''Desmoglein 1''', also known as '''DSG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.<ref>{{cite web | title = Entrez Gene: DSG1 desmoglein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1828| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Amagai M |title=Desmoglein as a target in autoimmunity and infection. |journal=J. Am. Acad. Dermatol. |volume=48 |issue= 2 |pages= 244-52 |year= 2003 |pmid= 12582396 |doi= 10.1067/mjd.2003.7 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DTNA... {November 9, 2007 4:36:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:39:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Dystrobrevin, alpha
| HGNCid = 3057
| Symbol = DTNA
| AltSymbols =; DRP3; D18S892E; DTN; LVNC1
| OMIM = 601239
| ECnumber =
| Homologene = 20362
| MGIid = 106039
| GeneAtlas_image1 = PBB_GE_DTNA_208430_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DTNA_210736_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_DTNA_211493_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006941 |text = striated muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007274 |text = neuromuscular synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1837
| Hs_Ensembl = ENSG00000134769
| Hs_RefseqProtein = NP_001381
| Hs_RefseqmRNA = NM_001390
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 30327279
| Hs_GenLoc_end = 30725341
| Hs_Uniprot = Q9Y4J8
| Mm_EntrezGene = 13527
| Mm_Ensembl = ENSMUSG00000024302
| Mm_RefseqmRNA = NM_010087
| Mm_RefseqProtein = NP_034217
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 23558452
| Mm_GenLoc_end = 23794673
| Mm_Uniprot = Q9D2N4
}}
}}
'''Dystrobrevin, alpha''', also known as '''DTNA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the dystrobrevin subfamily and the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. This protein may be involved in the formation and stability of synapses as well as the clustering of nicotinic acetylcholine receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: DTNA dystrobrevin, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1837| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Straub V, Campbell KP |title=Muscular dystrophies and the dystrophin-glycoprotein complex. |journal=Curr. Opin. Neurol. |volume=10 |issue= 2 |pages= 168-75 |year= 1997 |pmid= 9146999 |doi= }}
*{{cite journal | author=Ozawa E, Noguchi S, Mizuno Y, ''et al.'' |title=From dystrophinopathy to sarcoglycanopathy: evolution of a concept of muscular dystrophy. |journal=Muscle Nerve |volume=21 |issue= 4 |pages= 421-38 |year= 1998 |pmid= 9533777 |doi= }}
*{{cite journal | author=Blake DJ |title=Dystrobrevin dynamics in muscle-cell signalling: a possible target for therapeutic intervention in Duchenne muscular dystrophy? |journal=Neuromuscul. Disord. |volume=12 Suppl 1 |issue= |pages= S110-7 |year= 2002 |pmid= 12206805 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DVL1... {November 9, 2007 4:39:39 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 4:39:55 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:40:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DVL1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fsh.
| PDB = {{PDB2|1fsh}}, {{PDB2|1mc7}}
| Name = Dishevelled, dsh homolog 1 (Drosophila)
| HGNCid = 3084
| Symbol = DVL1
| AltSymbols =; DVL; MGC54245
| OMIM = 601365
| ECnumber =
| Homologene = 20926
| MGIid = 94941
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1855
| Hs_Ensembl =
| Hs_RefseqProtein = NP_004412
| Hs_RefseqmRNA = NM_004421
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 13542
| Mm_Ensembl = ENSMUSG00000029071
| Mm_RefseqmRNA = NM_010091
| Mm_RefseqProtein = NP_034221
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 4
| Mm_GenLoc_start = 154691212
| Mm_GenLoc_end = 154703103
| Mm_Uniprot = Q3TRW4
}}
}}
'''Dishevelled, dsh homolog 1 (Drosophila)''', also known as '''DVL1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: DVL1 dishevelled, dsh homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1855| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Wharton KA |title=Runnin' with the Dvl: proteins that associate with Dsh/Dvl and their significance to Wnt signal transduction. |journal=Dev. Biol. |volume=253 |issue= 1 |pages= 1-17 |year= 2003 |pmid= 12490194 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on ESRRA... {November 9, 2007 4:40:07 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 4:42:22 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:42:44 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ESRRA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lo1.
| PDB = {{PDB2|1lo1}}, {{PDB2|1xb7}}
| Name = Estrogen-related receptor alpha
| HGNCid = 3471
| Symbol = ESRRA
| AltSymbols =; ERR1; ERRa; ERRalpha; ESRL1; NR3B1
| OMIM = 601998
| ECnumber =
| Homologene = 20941
| MGIid = 1346831
| GeneAtlas_image1 = PBB_GE_ESRRA_1487_at_tn.png
| GeneAtlas_image2 = PBB_GE_ESRRA_203193_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2101
| Hs_Ensembl = ENSG00000173153
| Hs_RefseqProtein = NP_004442
| Hs_RefseqmRNA = NM_004451
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 63829616
| Hs_GenLoc_end = 63840786
| Hs_Uniprot = P11474
| Mm_EntrezGene = 26379
| Mm_Ensembl = ENSMUSG00000024955
| Mm_RefseqmRNA = NM_007953
| Mm_RefseqProtein = NP_031979
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 6978022
| Mm_GenLoc_end = 6988862
| Mm_Uniprot = Q3U110
}}
}}
'''Estrogen-related receptor alpha''', also known as '''ESRRA''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1.<ref>{{cite web | title = Entrez Gene: ESRRA estrogen-related receptor alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2101| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FKBP4... {November 9, 2007 4:42:44 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein FKBP4 image.jpg {November 9, 2007 4:43:53 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:44:14 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_FKBP4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n1a.
| PDB = {{PDB2|1n1a}}, {{PDB2|1p5q}}, {{PDB2|1q1c}}, {{PDB2|1qz2}}, {{PDB2|1rot}}, {{PDB2|1rou}}
| Name = FK506 binding protein 4, 59kDa
| HGNCid = 3720
| Symbol = FKBP4
| AltSymbols =; PPIase; FKBP52; FKBP59; HBI; Hsp56; p52
| OMIM = 600611
| ECnumber =
| Homologene = 36085
| MGIid = 95543
| GeneAtlas_image1 = PBB_GE_FKBP4_200895_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_FKBP4_200894_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003755 |text = peptidyl-prolyl cis-trans isomerase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0005528 |text = FK506 binding}} {{GNF_GO|id=GO:0016853 |text = isomerase activity}} {{GNF_GO|id=GO:0030674 |text = protein binding, bridging}} {{GNF_GO|id=GO:0031072 |text = heat shock protein binding}} {{GNF_GO|id=GO:0035259 |text = glucocorticoid receptor binding}} {{GNF_GO|id=GO:0051219 |text = phosphoprotein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006463 |text = steroid hormone receptor complex assembly}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0031503 |text = protein complex localization}} {{GNF_GO|id=GO:0046661 |text = male sex differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2288
| Hs_Ensembl = ENSG00000004478
| Hs_RefseqProtein = NP_002005
| Hs_RefseqmRNA = NM_002014
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 12
| Hs_GenLoc_start = 2774414
| Hs_GenLoc_end = 2783381
| Hs_Uniprot = Q02790
| Mm_EntrezGene = 14228
| Mm_Ensembl = ENSMUSG00000030357
| Mm_RefseqmRNA = NM_010219
| Mm_RefseqProtein = NP_034349
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 128395157
| Mm_GenLoc_end = 128404275
| Mm_Uniprot = Q8CBS1
}}
}}
'''FK506 binding protein 4, 59kDa''', also known as '''FKBP4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.<ref>{{cite web | title = Entrez Gene: FKBP4 FK506 binding protein 4, 59kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2288| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Schiene-Fischer C, Yu C |title=Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. |journal=FEBS Lett. |volume=495 |issue= 1-2 |pages= 1-6 |year= 2001 |pmid= 11322937 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on FPRL1... {November 9, 2007 4:44:14 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 4:45:23 PM PST}
- CREATED: Created new protein page: FPRL1 {November 9, 2007 4:45:31 PM PST}
- INFO: Beginning work on GABRB3... {November 9, 2007 4:45:31 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 4:46:13 PM PST}
- CREATED: Created new protein page: GABRB3 {November 9, 2007 4:46:21 PM PST}
- INFO: Beginning work on GRIK2... {November 9, 2007 4:46:21 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein GRIK2 image.jpg {November 9, 2007 4:47:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:47:36 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_GRIK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1s50.
| PDB = {{PDB2|1s50}}, {{PDB2|1s7y}}, {{PDB2|1s9t}}, {{PDB2|1sd3}}, {{PDB2|1tt1}}, {{PDB2|1yae}}, {{PDB2|2i0b}}, {{PDB2|2i0c}}
| Name = Glutamate receptor, ionotropic, kainate 2
| HGNCid = 4580
| Symbol = GRIK2
| AltSymbols =; EAA4; GLR6; GLUR6; MGC74427
| OMIM = 138244
| ECnumber =
| Homologene = 40717
| MGIid = 95815
| GeneAtlas_image1 = PBB_GE_GRIK2_213845_at_tn.png
| GeneAtlas_image2 = PBB_GE_GRIK2_215655_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005234 |text = extracellular-glutamate-gated ion channel activity}} {{GNF_GO|id=GO:0015277 |text = kainate selective glutamate receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0007215 |text = glutamate signaling pathway}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0031557 |text = induction of programmed cell death in response to chemical stimulus}} {{GNF_GO|id=GO:0048172 |text = regulation of short-term neuronal synaptic plasticity}} {{GNF_GO|id=GO:0050806 |text = positive regulation of synaptic transmission}} {{GNF_GO|id=GO:0051402 |text = neuron apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2898
| Hs_Ensembl = ENSG00000164418
| Hs_RefseqProtein = NP_068775
| Hs_RefseqmRNA = NM_021956
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 101953385
| Hs_GenLoc_end = 102624651
| Hs_Uniprot = Q13002
| Mm_EntrezGene = 14806
| Mm_Ensembl = ENSMUSG00000056073
| Mm_RefseqmRNA = NM_010349
| Mm_RefseqProtein = NP_034479
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 10
| Mm_GenLoc_start = 48789583
| Mm_GenLoc_end = 49471674
| Mm_Uniprot = P39087
}}
}}
'''Glutamate receptor, ionotropic, kainate 2''', also known as '''GRIK2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a subunit of a kainate glutamate receptor. Glutamate receptors mediate the majority of excitatory neurotransmission in the brain. This receptor may have a role in synaptic plasticity and may be important for learning and memory. It also may be involved in the transmission of light information from the retina to the hypothalamus. The structure and function of the encoded protein is changed by RNA editing. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene.<ref>{{cite web | title = Entrez Gene: GRIK2 glutamate receptor, ionotropic, kainate 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2898| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Seeburg PH, Higuchi M, Sprengel R |title=RNA editing of brain glutamate receptor channels: mechanism and physiology. |journal=Brain Res. Brain Res. Rev. |volume=26 |issue= 2-3 |pages= 217-29 |year= 1998 |pmid= 9651532 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on GTF2H4... {November 9, 2007 4:47:36 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:48:19 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = General transcription factor IIH, polypeptide 4, 52kDa
| HGNCid = 4658
| Symbol = GTF2H4
| AltSymbols =; TFIIH
| OMIM = 601760
| ECnumber =
| Homologene = 7090
| MGIid = 1338799
| GeneAtlas_image1 = PBB_GE_GTF2H4_203577_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005675 |text = holo TFIIH complex}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 2968
| Hs_Ensembl = ENSG00000137411
| Hs_RefseqProtein = NP_001508
| Hs_RefseqmRNA = NM_001517
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 30983997
| Hs_GenLoc_end = 31002215
| Hs_Uniprot = Q92759
| Mm_EntrezGene = 14885
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_010364
| Mm_RefseqProtein = NP_034494
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''General transcription factor IIH, polypeptide 4, 52kDa''', also known as '''GTF2H4''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24-7 |year= 1998 |pmid= 9570510 |doi= }}
*{{cite journal | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447-9 |year= 1998 |pmid= 9651670 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HSPB8... {November 9, 2007 4:51:13 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 4:52:02 PM PST}
- CREATED: Created new protein page: HSPB8 {November 9, 2007 4:52:10 PM PST}
- INFO: Beginning work on HTRA2... {November 9, 2007 4:52:56 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HTRA2 image.jpg {November 9, 2007 4:53:48 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:54:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HTRA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lcy.
| PDB = {{PDB2|1lcy}}
| Name = HtrA serine peptidase 2
| HGNCid = 14348
| Symbol = HTRA2
| AltSymbols =; OMI; PARK13; PRSS25
| OMIM = 606441
| ECnumber =
| Homologene = 8300
| MGIid = 1928676
| GeneAtlas_image1 = PBB_GE_HTRA2_211152_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HTRA2_203089_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004252 |text = serine-type endopeptidase activity}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005758 |text = mitochondrial intermembrane space}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005789 |text = endoplasmic reticulum membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007005 |text = mitochondrion organization and biogenesis}} {{GNF_GO|id=GO:0007628 |text = adult walking behavior}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}} {{GNF_GO|id=GO:0030900 |text = forebrain development}} {{GNF_GO|id=GO:0040014 |text = regulation of body size}} {{GNF_GO|id=GO:0048666 |text = neuron development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 27429
| Hs_Ensembl = ENSG00000115317
| Hs_RefseqProtein = NP_037379
| Hs_RefseqmRNA = NM_013247
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 74610040
| Hs_GenLoc_end = 74614191
| Hs_Uniprot = O43464
| Mm_EntrezGene = 64704
| Mm_Ensembl = ENSMUSG00000068329
| Mm_RefseqmRNA = NM_019752
| Mm_RefseqProtein = NP_062726
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 6
| Mm_GenLoc_start = 83016938
| Mm_GenLoc_end = 83020229
| Mm_Uniprot = Q3TXN0
}}
}}
'''HtrA serine peptidase 2''', also known as '''HTRA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.<ref>{{cite web | title = Entrez Gene: HTRA2 HtrA serine peptidase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27429| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Zurawa-Janicka D, Narkiewicz J, Lipińska B |title=[Characterization of the HtrA family of proteins] |journal=Postepy Biochem. |volume=53 |issue= 1 |pages= 27-36 |year= 2007 |pmid= 17718385 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LAMB1... {November 9, 2007 4:48:19 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:49:18 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Laminin, beta 1
| HGNCid = 6486
| Symbol = LAMB1
| AltSymbols =; CLM; MGC142015
| OMIM = 150240
| ECnumber =
| Homologene = 1722
| MGIid = 96743
| GeneAtlas_image1 = PBB_GE_LAMB1_201505_at_tn.png
| GeneAtlas_image2 = PBB_GE_LAMB1_211651_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005201 |text = extracellular matrix structural constituent}} {{GNF_GO|id=GO:0019899 |text = enzyme binding}}
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005606 |text = laminin-1 complex}} {{GNF_GO|id=GO:0005607 |text = laminin-2 complex}} {{GNF_GO|id=GO:0043257 |text = laminin-8 complex}} {{GNF_GO|id=GO:0043259 |text = laminin-10 complex}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007566 |text = embryo implantation}} {{GNF_GO|id=GO:0030335 |text = positive regulation of cell migration}} {{GNF_GO|id=GO:0031175 |text = neurite development}} {{GNF_GO|id=GO:0042476 |text = odontogenesis}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3912
| Hs_Ensembl = ENSG00000091136
| Hs_RefseqProtein = NP_002282
| Hs_RefseqmRNA = NM_002291
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 7
| Hs_GenLoc_start = 107351499
| Hs_GenLoc_end = 107431040
| Hs_Uniprot = P07942
| Mm_EntrezGene = 16777
| Mm_Ensembl = ENSMUSG00000002900
| Mm_RefseqmRNA = NM_008482
| Mm_RefseqProtein = NP_032508
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 12
| Mm_GenLoc_start = 31851443
| Mm_GenLoc_end = 31915700
| Mm_Uniprot = Q0V927
}}
}}
'''Laminin, beta 1''', also known as '''LAMB1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.<ref>{{cite web | title = Entrez Gene: LAMB1 laminin, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3912| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ljubimova JY, Fujita M, Khazenzon NM, ''et al.'' |title=Changes in laminin isoforms associated with brain tumor invasion and angiogenesis. |journal=Front. Biosci. |volume=11 |issue= |pages= 81-8 |year= 2006 |pmid= 16146715 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LBP... {November 9, 2007 4:49:18 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:50:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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| require_manual_inspection = no
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Lipopolysaccharide binding protein
| HGNCid = 6517
| Symbol = LBP
| AltSymbols =; MGC22233
| OMIM = 151990
| ECnumber =
| Homologene = 3055
| MGIid = 1098776
| GeneAtlas_image1 = PBB_GE_LBP_214461_at_tn.png
| GeneAtlas_image2 = PBB_GE_LBP_211652_s_at_tn.png
| Function = {{GNF_GO|id=GO:0001530 |text = lipopolysaccharide binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0006953 |text = acute-phase response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 3929
| Hs_Ensembl = ENSG00000129988
| Hs_RefseqProtein = NP_004130
| Hs_RefseqmRNA = NM_004139
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 36408299
| Hs_GenLoc_end = 36439067
| Hs_Uniprot = P18428
| Mm_EntrezGene = 16803
| Mm_Ensembl = ENSMUSG00000016024
| Mm_RefseqmRNA = NM_008489
| Mm_RefseqProtein = NP_032515
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 157997986
| Mm_GenLoc_end = 158023737
| Mm_Uniprot = Q61805
}}
}}
'''Lipopolysaccharide binding protein''', also known as '''LBP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.<ref>{{cite web | title = Entrez Gene: LBP lipopolysaccharide binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3929| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on LDHA... {November 9, 2007 4:50:16 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein LDHA image.jpg {November 9, 2007 4:50:50 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 4:51:06 PM PST}
- CREATED: Created new protein page: LDHA {November 9, 2007 4:51:13 PM PST}
- INFO: Beginning work on PCSK9... {November 9, 2007 4:54:04 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PCSK9 image.jpg {November 9, 2007 4:54:26 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 4:54:43 PM PST}
- CREATED: Created new protein page: PCSK9 {November 9, 2007 4:54:50 PM PST}
- INFO: Beginning work on POLL... {November 9, 2007 4:52:10 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein POLL image.jpg {November 9, 2007 4:52:43 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 4:52:56 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_POLL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nzp.
| PDB = {{PDB2|1nzp}}, {{PDB2|1rzt}}, {{PDB2|1xsl}}, {{PDB2|1xsn}}, {{PDB2|1xsp}}, {{PDB2|2bcq}}, {{PDB2|2bcr}}, {{PDB2|2bcs}}, {{PDB2|2bcu}}, {{PDB2|2bcv}}, {{PDB2|2gws}}, {{PDB2|2pfn}}, {{PDB2|2pfo}}, {{PDB2|2pfp}}, {{PDB2|2pfq}}
| Name = Polymerase (DNA directed), lambda
| HGNCid = 9184
| Symbol = POLL
| AltSymbols =; BETA-N; FLJ46002; POL-KAPPA
| OMIM = 606343
| ECnumber =
| Homologene = 40863
| MGIid = 1889000
| GeneAtlas_image1 = PBB_GE_POLL_221049_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003890 |text = beta DNA polymerase activity}} {{GNF_GO|id=GO:0016449 |text = lambda DNA polymerase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016829 |text = lyase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006289 |text = nucleotide-excision repair}} {{GNF_GO|id=GO:0016446 |text = somatic hypermutation of immunoglobulin genes}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 27343
| Hs_Ensembl = ENSG00000166169
| Hs_RefseqProtein = NP_037406
| Hs_RefseqmRNA = NM_013274
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 10
| Hs_GenLoc_start = 103328629
| Hs_GenLoc_end = 103338004
| Hs_Uniprot = Q9UGP5
| Mm_EntrezGene = 56626
| Mm_Ensembl = ENSMUSG00000025218
| Mm_RefseqmRNA = NM_020032
| Mm_RefseqProtein = NP_064416
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 45605586
| Mm_GenLoc_end = 45613854
| Mm_Uniprot = Q9QXE2
}}
}}
'''Polymerase (DNA directed), lambda''', also known as '''POLL''', is a human [[gene]].
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==Further reading==
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*{{cite journal | author=Niida H, Nakanishi M |title=[A novel mammalian DNA polymerase: DNA polymerase lambda (pol lambda)] |journal=Seikagaku |volume=74 |issue= 3 |pages= 224-6 |year= 2002 |pmid= 11974915 |doi= }}
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