1-Indanone

1-Indanone is the organic compound with the formula C6H4(CH2)2CO. It is one of two isomeric benzocyclopentanones, the other being 2-indanone. It is a colorless solid. 1-Indanone is a substrate for the enzyme indanol dehydrogenase.

Preparation
It is prepared by oxidation of indane or indene. It can also be prepared by cyclization of phenylpropionic acid.
 * [[image:1-Indanone Synthesis V.1.svg|300px]]

List of Drugs

 * 1) 2-Aminoindan synthesis (MDAI methodology using beta-keto-oxime formation with isoamylnitrite followed by reduction)
 * 2) Drinidene
 * 3) LNK-121
 * 4) Pirandamine
 * 5) Pyrophendane
 * 6) SKF Derivatives
 * 7) Indane analog of nisoxetine or Prozac.