1721 in Wales

This article is about the particular significance of the year 1721 to Wales and its people.

Incumbents

 * Lord Lieutenant of North Wales (Lord Lieutenant of Anglesey, Caernarvonshire, Denbighshire, Flintshire, Merionethshire, Montgomeryshire) – Hugh Cholmondeley, 1st Earl of Cholmondeley
 * Lord Lieutenant of Glamorgan – vacant until 1729
 * Lord Lieutenant of Brecknockshire and Lord Lieutenant of Monmouthshire – Sir William Morgan of Tredegar (from 7 March)
 * Lord Lieutenant of Cardiganshire – John Vaughan, 1st Viscount Lisburne (until 20 March); John Vaughan, 2nd Viscount Lisburne (from 21 March)
 * Lord Lieutenant of Carmarthenshire – vacant until 1755
 * Lord Lieutenant of Pembrokeshire – Sir Arthur Owen, 3rd Baronet
 * Lord Lieutenant of Radnorshire – Thomas Coningsby, 1st Earl Coningsby (until 11 September); James Brydges, 1st Duke of Chandos (from 11 September)
 * Bishop of Bangor – Benjamin Hoadly (until 7 November); Richard Reynolds (from 3 December)
 * Bishop of Llandaff – John Tyler
 * Bishop of St Asaph – John Wynne
 * Bishop of St Davids – Adam Ottley

Events

 * 11 January – Printer Isaac Carter marries Ann Lewis at Cenarth.
 * May – Prince William, the youngest child of the Prince and Princess of Wales, is taken ill with suspected smallpox; it turns out to be a false alarm, but inoculation becomes popular among aristocratic families as well as the royal family.
 * 30 December – Bridget Vaughan marries Arthur Bevan, a barrister.

New books

 * Ellis Pugh – Annerch ir Cymru (first Welsh book published in America)
 * John Prichard Prys – Difyrwch Crefyddol

Births

 * 17 March – Jonathan Hughes, poet (died 1805)
 * 30 November – John Egerton, bishop of Bangor (died 1787)
 * date unknown – John Walters, lexicographer
 * probable – Hugh Williams, Anglican priest and writer (died 1779)

Deaths

 * 20 March – John Vaughan, 1st Viscount Lisburne, Lord Lieutenant of Cardiganshire and former MP for Cardiganshire, 53
 * 8 July – Elihu Yale, American-born East India merchant and benefactor of Yale University, 72 (died in London)
 * 28 July – Sir Edward Williams, MP, 61
 * 3 September – Sir William Glynne, 2nd Baronet, 58
 * 5 September – Thomas Edwards, orientalist, 69