1880 Worcester Worcesters season

The 1880 season was the first for the Worcester Worcesters franchise in the National League, having played 1879 in the National Association. The team finished its initial season with a 40–43 record, good for fifth place. Lee Richmond threw a perfect game on June 12, 1880, the first ever perfect game in Major League Baseball history in a 1–0 victory over the Cleveland Blues. On August 20, they became the first major-league team to be no-hit at home when Pud Galvin of the Buffalo Bisons defeated them, 1–0.

Starters by position
''Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in''

Other batters
''Note: G = Games played; AB = At bats; H = Hits; Avg. = Batting average; HR = Home runs; RBI = Runs batted in''

Starting pitchers
Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts

Relief pitchers
Note: G = Games pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts