1942 United States Senate election in Oklahoma

The 1942 United States Senate election in Oklahoma took place on November 3, 1942. Incumbent Democratic Senator Joshua B. Lee ran for re-election to a second consecutive term. After winning the Democratic primary against several strong opponents, Lee advanced to the general election, where he was originally set to face former Republican Senator William B. Pine. However, shortly after winning the Republican primary, Pine died; the state Republican Party tapped businessman Edward H. Moore as its replacement nominee. In a favorable Republican environment, Moore defeated Lee by a wide margin to win his first and only term in the U.S. Senate.

Candidates

 * Joshua B. Lee, incumbent U.S. Senator
 * Orel Busby, former Justice on the Oklahoma Supreme Court
 * William H. Murray, former Governor of Oklahoma
 * Wilbur Wright
 * Dan Nelson
 * Paul V. Beck
 * Mark Long
 * George H. Brasler
 * Lilly Allen Lasley
 * Clay Woodrow England

Candidates

 * William B. Pine, former U.S. Senator
 * S. M. Stauffer
 * Frank A. Anderson

Results
After he won the Republican primary, William B. Pine died, leaving a vacancy on the Republican ticket. The Republican Party selected wealthy businessman Edward H. Moore as its replacement nominee.