1981 Western Illinois Leathernecks football team

The 1981 Western Illinois Leathernecks football team represented Western Illinois University as a member of the Association of Mid-Continent Universities during the 1981 NCAA Division I-AA football season. They were led by third-year head coach Pete Rodriguez and played their home games at Hanson Field. The Leathernecks finished the season with a 5–6 record overall and a 2–1 record in conference play, making them conference co-champions with Eastern Illinois and Northern Iowa.