2000–01 Northwestern State Demons basketball team

The 2000–01 Northwestern State Demons basketball team represented Northwestern State University during the 2000–01 NCAA Division I men's basketball season. The Demons, led by 2nd year head coach Mike McConathy, played their home games at Prather Coliseum and were members of the Southland Conference. They finished the season 19–13, 11–9 in Southland play to finish in fourth place in the regular season standings. They were champions of the Southland Conference tournament, winning the championship game over McNeese State, to earn an automatic bid to the NCAA tournament – the first appearance in program history. As one of two No. 16 seeds in the Midwest region, Northwestern State defeated Winthrop in the play-in game. The Demons were then beaten by No. 1 seed Illinois in the opening round.

Schedule and results
!colspan=9 style=| Non-conference Regular season

!colspan=9 style=| Southland Regular season

!colspan=9 style=| Southland Conference tournament

!colspan=9 style=|NCAA tournament