2005–06 FA Premier Reserve League

The 2005-06 Premier Reserve League season was the seventh since its establishment, and the last to feature more than 20 teams. The Northern League was won by Manchester United Reserves, while the Southern League was won by Tottenham Hotspur Reserves.

Reserve League South
Pld = Matches played; W = Matches won; D = Matches drawn; L = Matches lost; F = Goals for; A = Goals against; GD = Goal difference; Pts = Points

North/South Play-off Shield
The north–south play-off was won by Manchester United Reserves, who beat Tottenham Hotspur Reserves 2–0 at Old Trafford on 4 May 2006.