2006 Primera B de Chile

The 2006 Primera B de Chile was the 56th completed season of the Primera B de Chile.

Deportes Melipilla was the tournament's champions. The other teams promoted were Ñublense (runner-up under Melipilla in the league's promotion playoffs) and Lota Schwager following beat C.S.D. Rangers in the shootout during the 2006 Primera División de Chile relegation playoffs. That match had to Cristián Limenza as the best, who saved two penalty kicks to Juan Cisternas and Miguel Ayala in the shootout. Nevertheless, on August 27, 2006, Magallanes lost the category and was relegated to Tercera División de Chile after being defeated 2–0 by Deportivo Temuco.