2008 La Serena Open – Singles

Mariano Zabaleta was the defending champion, but did not compete this year.

Rubén Ramírez Hidalgo won the title by defeating qualifier David Marrero 6–3, 6–1 in the final.

Seeds
• # 🇪🇨 Nicolás Lapentti (quarterfinals)

• # 🇪🇸 Rubén Ramírez Hidalgo (champion)

• # 🇦🇷 Juan Pablo Guzmán (first round)

• # 🇦🇷 Brian Dabul (second round)

• # 🇦🇷 Eduardo Schwank (semifinals)

• # 🇧🇷 Thomaz Bellucci (first round)

• # Adrián García (second round)

• # 🇪🇸 Daniel Muñoz de la Nava (first round)