2010 Calabasas Pro Tennis Championships – Singles

Donald Young was the defending champion; however, he was eliminated by Marinko Matosevic in the semifinals.

Matosevic won in the final match 2–6, 6–4, 6–3, against Ryan Sweeting.

Seeds
• # 🇺🇸 Donald Young (semifinals)

• # 🇺🇸 Ryan Sweeting (final)

• # 🇺🇸 Robert Kendrick (semifinals)

• # 🇦🇺 Carsten Ball (first round)

• # Izak van der Merwe (first round)

• # 🇦🇺 Marinko Matosevic (champion)

• # 🇺🇸 Kevin Kim (first round)

• # 🇦🇺 John Millman (first round)