2010 Città di Caltanissetta – Singles

Jesse Huta Galung was the defending champion, but he lost to Albert Ramos Viñolas in the first round.

The new champion was another Dutch player, Robin Haase, who won in the final 7–5, 6–3, against Matteo Trevisan.

Seeds
• # 🇪🇸 Santiago Ventura (first round)

• # 🇮🇹 Paolo Lorenzi (quarterfinals)

• # 🇪🇸 Pere Riba (quarterfinals)

• # 🇪🇸 Iván Navarro (semifinals)

• # 🇪🇸 Rubén Ramírez Hidalgo (second round)

• # Grega Žemlja (semifinals)

• # 🇪🇸 David Marrero (first round)

• # 🇨🇿 Ivo Minář (first round)