2010 Città di Como Challenger – Singles

Alexandr Dolgopolov was the defending champion, but chose not to compete this year. Robin Haase won the final against Ivo Minář 6–4, 6–3.

Seeds
• # Robin Haase (champion)

• # 🇮🇹 Filippo Volandri (semifinals)

• # 🇮🇹 Paolo Lorenzi (first round)

• # 🇩🇪 Julian Reister (semifinals, retired)

• # 🇧🇪 Steve Darcis (quarterfinals, withdrew due to a neck injury)

• # 🇪🇸 Albert Ramos Viñolas (first round)

• # 🇷🇴 Adrian Ungur (second round)

• # Rui Machado (quarterfinals)