2010 Copa Petrobras Buenos Aires – Singles

Horacio Zeballos won last year's edition, but decided not to participate this year.

Máximo González won the title, by defeating top seed Pablo Cuevas 6–4, 6–3 in the final.

Seeds
• # Pablo Cuevas (final)

• # 🇮🇹 Fabio Fognini (second round)

• # 🇦🇷 Brian Dabul (second round)

• # 🇦🇷 Carlos Berlocq (semifinals)

• # Rui Machado (second round)

• # Nicolás Massú (second round, withdrew due to left foot injury)

• # Ramón Delgado (first round)

• # 🇦🇷 Federico del Bonis (second round)