2010 Copa Petrobras Montevideo – Singles

Pablo Cuevas was the defending champion. He reached the final, but he lost to Máximo González 6–1, 3–6, 4–6.

Seeds
• # Pablo Cuevas (final)

• # 🇦🇷 Brian Dabul (quarterfinals)

• # 🇦🇷 Carlos Berlocq (quarterfinals)

• # Rui Machado (second round, retired)

• # Nicolás Massú (first round)

• # 🇪🇸 Santiago Ventura (first round)

• # 🇦🇷 Federico Delbonis (quarterfinals)

• # 🇦🇷 Diego Junqueira (second round)