2010 Karshi Challenger – Singles

Rainer Eitzinger was the champion in 2009, but he decided to not compete this year. Blaž Kavčič won the final against Michael Venus 7–6(6), 7–6(5).

Seeds
• # Blaž Kavčič (champion)

• # 🇷🇺 Konstantin Kravchuk (second round)

• # 🇸🇰 Andrej Martin (second round)

• # 🇸🇰 Marek Semjan (quarterfinals)

• # 🇷🇺 Andrey Kumantsov (second round)

• # Andis Juška (second round, retired due to stomachache)

• # 🇨🇿 Jan Minář (quarterfinals)

• # 🇪🇸 Carles Poch Gradin (quarterfinals)