2010 Roma Open – Singles

Daniel Köllerer was the defender of championship title, however lost to Federico del Bonis in the quarterfinals.

del Bonis won in the final 6–4, 6–3, against Florian Mayer.

Seeds
• # 🇩🇪 Florian Mayer (final)

• # 🇩🇪 Daniel Brands (quarterfinals)

• # 🇦🇹 Daniel Köllerer (quarterfinals)

• # 🇮🇹 Paolo Lorenzi (withdrew)

• # Rui Machado (semifinals)

• # Frederico Gil (second round)

• # 🇪🇸 Rubén Ramírez Hidalgo (semifinals)

• # 🇯🇲 Dustin Brown (withdrew due to fatigue)