2010 Tennis Napoli Cup – Singles

Pablo Cuevas was the defending champion, however he chose not to participate this year.

Rui Machado won the title, defeating Federico Delbonis 6–4, 6–4 in the final.

Seeds
• # 🇮🇹 Potito Starace (second round)

• # 🇮🇹 Paolo Lorenzi (second round)

• # 🇰🇿 Andrey Golubev (semifinals)

• # Blaž Kavčič (first round)

• # 🇷🇺 Igor Kunitsyn (first round)

• # 🇪🇸 Pere Riba (withdrew)

• # 🇷🇴 Victor Crivoi (first round)

• # Rui Machado (champion)