2012 Aberto de São Paulo – Singles

Ricardo Mello was the defending champion but decided not to participate. Thiago Alves won the title after defeating Gastão Elias 7–6(7–5), 7–6(7–1) in the final.

Seeds
• # 🇦🇷 Horacio Zeballos (quarterfinals)

• # 🇧🇷 Rogério Dutra da Silva (semifinals)

• # 🇧🇷 Júlio Silva (first round)

• # 🇦🇷 Federico Delbonis (semifinals)

• # Gastão Elias (final)

• # 🇧🇷 Caio Zampieri (first round)

• # 🇨🇴 Eduardo Struvay (first round)

• # 🇦🇷 Juan Pablo Brzezicki (second round, retired)