2012 JSM Challenger of Champaign–Urbana – Singles

Alex Kuznetsov was the defending champion. Tim Smyczek defeated Jack Sock 2–6, 7–6(7–1), 7–5 in the final to win the title.

Seeds
• # 🇺🇸 Michael Russell (quarterfinals, retired)

• # 🇩🇪 Mischa Zverev (first round)

• # 🇺🇸 Denis Kudla (second round)

• # 🇺🇸 Ryan Sweeting (quarterfinals)

• # 🇺🇸 Bobby Reynolds (first round)

• # 🇺🇸 Tim Smyczek (champion)

• # 🇺🇸 Jack Sock (final)

• # 🇺🇸 Alex Kuznetsov (first round)