2012 Open GDF Suez Nantes Atlantique – Singles

Alison Riske was the defending champion but lost to Yulia Putintseva in the second round.

Monica Niculescu won the title, defeating Putintseva in the final, 6–2, 6–3.

Seeds
• # 🇨🇿 Petra Cetkovská (second round)

• # 🇷🇴 Monica Niculescu (champion)

• # 🇷🇴 Alexandra Cadanțu (first round)

• # 🇫🇷 Stéphanie Foretz Gacon (first round)

• # 🇪🇸 Garbiñe Muguruza (first round)

• # 🇨🇿 Kristýna Plíšková (first round)

• # 🇨🇿 Karolína Plíšková (quarterfinals)

• # 🇦🇹 Yvonne Meusburger (first round)