2012 San Luis Potosí Challenger – Singles

Santiago Giraldo was the defending champion but decided not to participate. Spanish Rubén Ramírez Hidalgo won the tournament with the score 3–6, 6–3, 6–4 in the final against Paolo Lorenzi.

Seeds
• # 🇮🇹 Paolo Lorenzi (final)

• # 🇪🇸 Rubén Ramírez Hidalgo (champion)

• # 🇪🇸 Arnau Brugués Davi (first round, retired)

• # 🇮🇹 Matteo Viola (first round)

• # 🇨🇿 Jan Mertl (first round)

• # 🇨🇦 Érik Chvojka (second round)

• # 🇲🇩 Roman Borvanov (first round)

• # 🇨🇴 Alejandro González (first round)