2012 Tallahassee Tennis Challenger – Singles

Donald Young was the defending champion but decided not to participate. Tim Smyczek won the title, when Frank Dancevic retired in the final after losing the first set 5–7.

Seeds
• # Yen-Hsun Lu (withdrew due to a neck injury)

• # 🇺🇸 Ryan Sweeting (quarterfinals)

• # 🇷🇺 Igor Kunitsyn (quarterfinals)

• # 🇯🇵 Tatsuma Ito (semifinals)

• # 🇨🇦 Vasek Pospisil (first round)

• # 🇺🇸 Wayne Odesnik (quarterfinals)

• # 🇧🇷 Rogério Dutra da Silva (second round)

• # 🇺🇸 Bobby Reynolds (quarterfinals)

• # 🇨🇦 Frank Dancevic (final, retired)