2016 Amex-Istanbul Challenger – Singles

Karen Khachanov was the defending champion but chose not to participate.

Malek Jaziri won the title after defeating Dudi Sela 1–6, 6–1, 6–0 in the final.

Seeds
• # 🇹🇳 Malek Jaziri (champion)

• # 🇮🇱 Dudi Sela (final)

• # 🇩🇪 Tobias Kamke (semifinals)

• # Marco Chiudinelli (semifinals)

• # 🇷🇴 Marius Copil (quarterfinals)

• # 🇪🇸 Adrián Menéndez-Maceiras (second round)

• # 🇧🇦 Aldin Šetkić (first round)

• # 🇷🇸 Nikola Milojević (first round)