2016 Internationaux de Tennis de Vendée – Singles

Benoît Paire was the defending champion but lost in the semifinals to Andrey Rublev.

Julien Benneteau won the title after defeating Rublev 7–5, 2–6, 6–3 in the final.

Seeds
• # 🇫🇷 Benoît Paire (semifinals)

• # 🇷🇺 Mikhail Youzhny (first round)

• # 🇫🇷 Paul-Henri Mathieu (first round)

• # 🇷🇺 Konstantin Kravchuk (second round)

• # 🇲🇩 Radu Albot (second round)

• # Nikoloz Basilashvili (first round)

• # Marco Chiudinelli (second round)

• # 🇩🇪 Tobias Kamke (first round)