2016 JSM Challenger of Champaign–Urbana – Singles

Henri Laaksonen was the defending champion and successfully defended his title by defeating Ruben Bemelmans 7–5, 6–3 in the final.

Seeds
• # 🇺🇸 Jared Donaldson (semifinals)

• # Henri Laaksonen (champion)

• # 🇺🇸 Stefan Kozlov (second round)

• # 🇧🇪 Joris De Loore (first round)

• # 🇦🇺 Sam Groth (first round, retired)

• # 🇧🇪 Ruben Bemelmans (final)

• # 🇺🇸 Noah Rubin (first round)

• # 🇺🇸 Reilly Opelka (second round)