2016 Open Engie Saint-Gaudens Midi-Pyrénées – Singles

María Teresa Torró Flor was the defending champion, but chose not to participate.

Irina Khromacheva won the title, defeating Maria Sakkari in the final, 1–6, 7–6(7–3), 6–1.

Seeds
• # 🇪🇸 Lourdes Domínguez Lino (second round)

• # Maria Sakkari (final)

• # 🇦🇹 Tamira Paszek (second round)

• # Viktorija Golubic (quarterfinals)

• # Romina Oprandi (withdrew)

• # 🇯🇵 Miyu Kato (first round)

• # 🇧🇪 Ysaline Bonaventure (first round)

• # Amra Sadiković (quarterfinals)