2016 Open Harmonie mutuelle – Singles

Nicolas Mahut was the defending champion, but chose not to defend his title.

Alexandre Sidorenko won the title, defeating Igor Sijsling 2–6, 6–3, 7–6(7–3) in the final.

Seeds
• # 🇩🇪 Jan-Lennard Struff (second round)

• # 🇬🇧 Daniel Evans (quarterfinals)

• # 🇷🇺 Karen Khachanov (second round)

• # 🇮🇹 Luca Vanni (first round)

• # 🇫🇷 Vincent Millot (first round)

• # Igor Sijsling (final)

• # 🇧🇾 Egor Gerasimov (first round)

• # 🇫🇷 Quentin Halys (first round)