2016 San Antonio Open – Singles

This was the first edition of the tournament. Misaki Doi won the title, defeating in the final Anna-Lena Friedsam with the score 6–4, 6–2.

Seeds
• #🇦🇺 Daria Gavrilova (quarterfinals)

• #🇷🇴 Irina-Camelia Begu (first round)

• # Jeļena Ostapenko (first round)

• #🇧🇪 Yanina Wickmayer (first round)

• #🇧🇷 Teliana Pereira (first round)

• #🇯🇵 Misaki Doi (champion)

• #🇧🇪 Kirsten Flipkens (second round)

• #🇯🇵 Nao Hibino (first round)