2016 Santiago Challenger – Singles

Rogério Dutra Silva was the defending champion but lost in the final to Máximo González.

González won the title after defeating Dutra Silva 6–2, 7–6(7–5) in the final.

Seeds
• # 🇦🇷 Horacio Zeballos (semifinals)

• # 🇧🇷 Thiago Monteiro (semifinals, retired)

• # 🇦🇷 Renzo Olivo (withdrew)

• # 🇧🇷 Rogério Dutra Silva (final)

• # 🇧🇷 João Souza (first round)

• # 🇦🇷 Guido Andreozzi (second round)

• # 🇦🇷 Leonardo Mayer (second round)

• # 🇦🇷 Nicolás Kicker (second round)