2016 Tallahassee Tennis Challenger – Singles

Facundo Argüello was the defending champion but lost in the first round to Frances Tiafoe.

Quentin Halys won the title, defeating Frances Tiafoe 6–7(6–8), 6–4, 6–2 in the final.

Seeds
• # 🇺🇸 Donald Young (quarterfinals)

• # 🇦🇹 Gerald Melzer (second round)

• # 🇺🇸 Tim Smyczek (first round)

• # 🇺🇸 Bjorn Fratangelo (first round)

• # Nikoloz Basilashvili (second round)

• # 🇦🇷 Facundo Argüello (first round)

• # 🇺🇸 Jared Donaldson (first round)

• # 🇺🇸 Dennis Novikov (first round)