2016 Tashkent Challenger – Singles

Denis Istomin was the defending champion but lost in the final to Konstantin Kravchuk.

Kravchuk won the title defeating Istomin 7–5, 6–4 in the final.

Seeds
• # 🇨🇿 Jiří Veselý (second round, retired)

• # 🇫🇷 Jérémy Chardy (quarterfinals)

• # 🇱🇹 Ričardas Berankis (second round, retired)

• # 🇷🇺 Evgeny Donskoy (first round)

• # 🇷🇺 Konstantin Kravchuk (champion)

• # 🇸🇰 Lukáš Lacko (semifinals)

• # 🇺🇿 Denis Istomin (final)

• # 🇧🇦 Mirza Bašić (semifinals)