2018 Città di Caltanissetta – Singles

Paolo Lorenzi was the defending champion but lost in the first round to Alejandro Davidovich Fokina.

Jaume Munar won the title after defeating Matteo Donati 6–2, 7–6(7–2) in the final.

Seeds
• # 🇮🇹 Paolo Lorenzi (first round)

• # Pablo Cuevas (quarterfinals)

• # 🇨🇿 Jiří Veselý (quarterfinals)

• # 🇯🇵 Taro Daniel (withdrew)

• # 🇷🇸 Laslo Đere (first round)

• # 🇦🇷 Guido Andreozzi (first round)

• # 🇧🇷 Thiago Monteiro (first round)

• # 🇮🇹 Stefano Travaglia (withdrew)