2018 Columbus Challenger – Singles

Ante Pavić was the defending champion but chose not to defend his title.

Michael Mmoh won the title after defeating Jordan Thompson 6–3, 7–6(7–4) in the final.

Seeds
• # 🇦🇺 Jordan Thompson (final)

• # 🇨🇦 Peter Polansky (second round)

• # 🇺🇸 Michael Mmoh (champion)

• # 🇺🇸 Reilly Opelka (withdrew)

• # 🇩🇪 Dominik Köpfer (quarterfinals)

• # 🇦🇺 Alexei Popyrin (quarterfinals)

• # 🇪🇨 Roberto Quiroz (semifinals)

• # 🇦🇺 Maverick Banes (first round)