2018 Dow Tennis Classic – Singles

Tatjana Maria was the defending champion, but chose to compete at the 2018 St. Petersburg Ladies' Trophy instead.

Madison Brengle won the title, defeating Jamie Loeb in the final 6–1, 6–2.

Seeds
• # 🇷🇴 Mihaela Buzărnescu (semifinals)

• # 🇺🇸 Jennifer Brady (semifinals)

• # 🇺🇸 Madison Brengle (champion)

• # 🇺🇸 Sofia Kenin (second round)

• # 🇺🇸 Sachia Vickery (second round, retired)

• # Richèl Hogenkamp (first round)

• # 🇨🇴 Mariana Duque Mariño (first round)

• # 🇷🇺 Evgeniya Rodina (quarterfinals)