2018 Jalisco Open – Singles

Mirza Bašić was the defending champion but chose not to defend his title.

Marcelo Arévalo won the title after defeating Christopher Eubanks 6–4, 5–7, 7–6(7–4) in the final.

Seeds
• # 🇪🇸 Adrián Menéndez Maceiras (second round)

• # 🇩🇪 Mats Moraing (quarterfinals)

• # 🇺🇸 Dennis Novikov (first round)

• # 🇨🇦 Filip Peliwo (second round)

• # 🇺🇸 Kevin King (first round)

• # Marcelo Arévalo (champion)

• # 🇩🇴 Víctor Estrella Burgos (second round)

• # Darian King (quarterfinals)