2020–21 CAF Confederation Cup knockout stage

The 2020–21 CAF Confederation Cup knockout stage started on 16 May with the quarter-finals and will conclude on 10 July 2021 with the final to decide the champions of the 2020–21 CAF Confederation Cup. A total of eight teams are competing in the knockout stage.

Times are GMT as listed by CAF (local times, even if not different, are in parentheses).

Round and draw dates
The schedule is as follows.

Format
Each tie in the knockout stage, apart from the final, is played over two legs, with each team playing one leg at home. The team that scores more goals on aggregate over the two legs advances to the next round. If the aggregate score is level, the away goals rule is applied, i.e. the team that scores more goals away from home over the two legs advances. If away goals are also equal, then extra time is not played and the winners are decided by a penalty shoot-out. In the final, which is played as a single match, if the score is level at the end of normal time, extra time won't also be played and the winners will be decided by a penalty shoot-out.  The mechanism of the draws for each round is as follows:
 * In the draw for the quarter-finals, the four group winners are seeded, and the four group runners-up are unseeded. The seeded teams are drawn against the unseeded teams, with the seeded teams hosting the second leg. Teams from the same group cannot be drawn against each other, while teams from the same association can be drawn against each other.
 * In the draws for semi-finals, there are no seedings, and teams from the same group or the same association can be drawn against each other. As the draws for the quarter-finals and semi-finals are held together before the quarter-finals are played, the identity of the quarter-final winners is not known at the time of the semi-final draw.

Qualified teams
The knockout stage involves the 8 teams which qualify as winners and runners-up of each of the eight groups in the group stage. 

Bracket
The bracket of the knockout stage is determined as follows:

 The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 30 April 2021, 14:00 CAT (UTC+2), at the CAF headquarters in Cairo, Egypt.



Quarter-finals
The draw for the quarter-finals was held on 30 April 2021.

Summary
The first legs were played on 16 May, and the second legs were played on 23 May 2021. 


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Matches
JS Kabylie won 2–1 on aggregate.

Raja Casablanca won 5–1 on aggregate.

Pyramids won 5–2 on aggregate.

''2–2 on aggregate. Coton Sport won on away goals.''

Semi-finals
The draw for the semi-finals was held on 30 April 2021 (after the quarter-finals draw).

Summary
The first legs were played on 20 June, and the second legs were played on 27 June 2021. 


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Matches
''0–0 on aggregate. Raja Casablanca won 5–4 on penalties.''

JS Kabylie won 5–1 on aggregate.

Final
 The final was played on 10 July 2021 at Stade de l'Amitié, Cotonou.

